85-4871-53　(10E)-9-Oxo-11-(3-pentyl-2-oxiranyl)-10-undecenoic Acid 100ug　CAS No:478931-82-7　411710

特徴

• Biologically active oxidative derivative of linoleic acid. During oxidative stress, the abundant unsaturated fatty acid linoleic acid undergoes lipid peroxidation to produce α,β-unsaturated epoxy-keto-octadecenoic acids (EKODEs). Nonenzymatic autooxidation of linoleic acid generates six major EKODE isomers, which differ from one another in the positioning and the orientation of the epoxy group relative to the keto moiety. trans-EKODE-(E)-Ib is a biologically active peroxidation product of linoleic acid that is characterized, structurally, by having a trans carbon-carbon double bond between the 9-keto and 12,13-epoxy groups. It activates an antioxidant response element (ARE) in neuronal cells and induces the expression of ARE-regulated cytoprotective genes like NQO1.1 This EKODE also stimulates the synthesis of aldosterone and corticosterone in adrenal cells when supplied at 1-5 μM.2,3 This effect appears to be mediated by a rise in intracellular calcium.4
• Synonyms:(E)-Ib-trans-EKODE; (10E)-9-Oxo-11-(3-pentyloxiranyl)-10-undecenoic Acid; 9-oxo-11-(3-pentyl-2-oxiranyl)-10E-undecenoic acid; 12,13-epoxy-9-keto-10(trans)-Octadecenoic Acid
• Molecular Formula:C₁₈H₃₀O₄
• Molecular Weight:310.43
• Appearance:Supplied as a solution in ethanol.
• Purity:≥98%
• Solubility:DMF: 50mg/mlDMSO: 50mg/mlEthanol: 50mg/mlPBS (pH 7.2): .5mg/m
• Storage and Stability:May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.