BTLA, also known as B- and T-lymphocyte attenuator isoform 1, is an inhibitory molecule which belongs to the Ig superfamily. It is a type 1 transmembrane glycoprotein in the CD28 family of T cell costimulatory molecules. This protein is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte- associated antigen 4 (CTLA-4) and programmed death 1(PD-1). Also, it is a ligand for tumor necrosis factor (receptor) superfamily, member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses. Recombinant human BTLA, fused to His-Tag at C-terminal, expressed in insect cell and purified by using conventional chromatography techniques.
Source:Recombinant protein corresponding to aa31-157 of human BTLA, fused to His-Tag at C-terminal, expressed in insect cell.
Molecular Weight:~15.7kD (136aa), ~18-28kD (SDS-PAGE under reducing conditions)
Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Source Antigen：Recombinant, Insect cell
Grade：Highly Purified
Purity：~90% (SDS-PAGE)
Form：Supplied as a liquid in PBS, pH 7.4, 10% glycerol.
