85-4780-22　Pepsinogen I (PGI, PGA, Pepsinogen A3/A4/A5, EC 3.4.23.1), Human 100ug　396821

特徴

• Human Pepsinogens are aspartic proteases produced in the gastric mucosa and secreted into the gastric lumen that play a major role in the digestion of proteins after activation of acidic pH. It is synthesized as isoymogens and are classified into two groups, Pepsinogen I and Pepsinogen II).
• Human PGA and PGC antigen have been investigated as a possible biomarker for early detection of, Gastric cancer (GC), adenoma (GA) and severe atrophic (diffuse or patchy) corpus gastritis.
• It has been reported that human Pepsinogen I (PGA) levels were lower in atrophic corpus gastritis than in atrophic antral gastritis, and human pepsinogen I (PGA) levels were lower in advanced gastric cancer than early stage gastric cancer.
• Synonyms:Pepsinogen A, PG I, PGA, Pepsinogen 1; E.C. Number 3.4.23.1; Gene: PGA3, PGA4, PGA5
• Molecular Weight:45kD
• Appearance:Supplied as a white, lyophilized powder in Tris-chloride, pH 8.5.
• Source:Human gastric mucosa
• Purity:≥90% by SDS-PAGE (identity confirmed by Western blot)
• Solubility:Clear colorless liquid at 1mg/ml in saline
• Specific Activity:Lot-dependent. ≥500U/mg protein (upon activation)Note: Pepsinogen self-activates upon exposure to low pH.
• Unit Definition of Activity: One unit will produce a ΔA280 of 0.001 per minute at pH 2.0 and 37°C, measured as TCA-soluble products from hemoglobin.
• Storage and Stability:Store lyophilized powder at -20°C for up to 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap.