85-4740-67　Hdac8, Recombinant, Mouse, aa1-377, His-Tag (Histone Deacetylase 8 Isoform 1) 10ug　377833

特徴

• Hdac8, also known as histone deacetylase 8 isoform 1, is a member of the class I Histone Deacetylases. Its specific inhibition reduces gene expression and production of proinflammatory cytokines in vitro and in vivo. It expressed in the renal epithelial cells of the mouse kidney. Its activity contributes to renal protection and functional recovery and is required for renal regeneration after AKI.
• Source:Recombinant protein corresponding to aa1-377 from mouse Hdac8, fused to His-Tag at C-terminal, expressed in insect cell.
• Molecular Weight:~42.5kD (383aa), 40-57kD (SDS-PAGE under reducing conditions)
• Endotoxin:<1EU/1ug (determined by LAL method)
• AA Sequence:MEMPEEPANS GHSLPPVYIY SPEYVSICDS LVKVPKRASM VHSLIEAYAL HKQMRIVKPK VASMEEMATF HTDAYLQHLQ KVSQEGDEDH PDSIEYGLGY DCPATEGIFD YAAAIGGGTI TAAQCLIDGK CKVAINWSGG WHHAKKDEAS GFCYLNDAVL GILRLRRKFD RILYVDLDLH HGDGVEDAFS FTSKVMTVSL HKFSPGFFPG TGDMSDVGLG KGRYYSVNVP IQDGIQDEKY YHICESVLKE VYQAFNPKAV VLQLGADTIA GDPMCSFNMT PVGIGKCLKY VLQWQLATLI LGGGGYNLAN TARCWTYLTG VILGKTLSSE IPDHEFFTAY GPDYVLEITP SCRPDRNEPH RIQQILNYIK GNLKHVVHHH HHH
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.