85-4740-18　Ctsd, Recombinant, Mouse, aa21-410, His-Tag (Cathepsin D, CatD, CD) 5ug　377779

特徴

• Ctsd, also known as cathepsin D, is peptidase belonging to the family of aspartic peptidases. It is intracellular catabolism in lysosomal compartments, other physiological effect include hormone and antigen processing. It plays an important role in alpha-synuclein degradation, and neuronal survival. It has also been shown to mediate apoptosis induced by various stimuli and p53-dependent tumor suppression.
• Source:Recombinant protein corresponding to aa24-188 from mouse Ctsd, fused to His-Tag at C-terminal, expressed in insect cell.
• Molecular Weight:~44.0kD (398aa), 40-57kD (SDS-PAGE under reducing conditions)
• Endotoxin:<1EU/1ug (determined by LAL method)
• Biological Activity:Specific activity is >1000pmol/min/ug in which one unit will convert 1pmole of Mca-PLGL-Dpa-AR-NH2 to MCA- Pro-Leu-OH/minute at pH 3.5 at 25°C.
• AA Sequence:IIRIPLRKFT SIRRTMTEVG GSVEDLILKG PITKYSMQSS PKTTEPVSEL LKNYLDAQYY GDIGIGTPPQ CFTVVFDTGS SNLWVPSIHC KILDIACWVH HKYNSDKSST YVKNGTSFDI HYGSGSLSGY LSQDTVSVPC KSDQSKARGI KVEKQIFGEA TKQPGIVFVA AKFDGILGMG YPHISVNNVL PVFDNLMQQK LVDKNIFSFY LNRDPEGQPG GELMLGGTDS KYYHGELSYL NVTRKAYWQV HMDQLEVGNE LTLCKGGCEA IVDTGTSLLV GPVEEVKELQ KAIGAVPLIQ GEYMIPCEKV SSLPTVYLKL GGKNYELHPD KYILKVSQGG KTICLSGFMG MDIPPPSGPL WILGDVFIGS YYTVFDRDNN RVGFANAVVL LEHHHHHH
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.