UNC0321 (trifluoroacetate salt) is a selective histone lysine methyltransferase (HMTase) inhibitor for G9a and GLP (also known as EHMT1), with IC50 of 6nM and 15nM, respectively. It is more than 40,000-fold more selective for G9a and GLP vs. SET7/9, SET8, PRMT3, or JMJD2E.
Formula:C27H45N7O3 • 3(CF3COOH)
Solubility:DMSO
Molecular Weight:~857.8D
Storage and Stability:Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Do not store aqueous solutions for more than one day. Anhydrous DMSO stock solutions are stable up to 2 weeks at +4°C or up to 6 months at –70°C.
