85-4692-23　Histone H2B Type 1-M, Recombinant, Mouse, aa2-126, His-Tag (Hist1h2bm) 20ug　373635

特徴

• Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
• Full-length recombinant protein corresponding to aa2-126 from mouse Histone H2B type 1-M, fused to 6X His-Tag at N-terminal, expressed in E. coli. Swiss/Uniprot: P10854
• Molecular Weight:~17.8kD
• Amino Acid Sequence:PEPTKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.