85-4685-06　Fasciculin-2, Recombinant, Dendroaspis angusticeps, aa1-61, His-SUMO-Tag (Fas-2) 20ug　373278

特徴

• Interferes with neuromuscular transmission by inhibiting the enzyme acetylcholinesterase (AChE) present at the neuromuscular junction. It selectively binds and inhibits with a 1:1 stoichiometry the mammalian and electric fish AChE at picomolar concentrations. It is highly specific for the peripheral site of AChE and blocks the entry of acetylcholine into the active site of the enzyme (through the Met-33 residue), thereby preventing its breakdown. It has been called fasciculin since after injection into mice it causes severe, generalized and long-lasting (5-7 hours) fasciculations.
• Source:Recombinant protein corresponding to aa1-61 from dendroaspis angusticeps Fasciculin-2, fused to His-SUMO-Tag at N-terminal expressed in E. coli.
• Molecular Weight:~22.8kD
• AA Sequence:TMCYSHTTTSRAILTNCGENSCYRKSRRHPPKMVLGRGCGCPPGDDNLEVKCCTSPDKCNY
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.