85-4678-91　Cytotoxin 4, Recombinant, Naja Atra, aa22-81, His-SUMO-Tag 20ug　372975

特徴

• Basic protein that bind to cell membrane and depolarizes cardiomyocytes. This cytotoxin also shows lytic activities, but 2-fold more important than that of CTX-A2. It binds to the integrin alpha-V/beta-3 with a moderate affinity. Inhibits protein kinase C. It may interact with sulfatides in the cell membrane, which induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It also may target the mitochondrial membrane and induces mitochondrial swelling and fragmentation.
• Source:Recombinant protein corresponding to aa22-81 from naja atra Cytotoxin 4, fused to His-SUMO-Tag at N-terminal, expressed in E. coli.
• Molecular Weight:~22.8kD
• AA Sequence:RKCNKLVPLFYKTCPAGKNLCYKMFMVSNLTVPVKRGCIDVCPKNSALVKYVCCNTDRCN
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.