85-4672-51 Cd163, Recombinant, Mouse, aa86-365, His-Tag (Scavenger Receptor Cysteine-rich Type 1 Protein M130) 20ug 372655
特徴
- Involved in clearance and endocytosis of hoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hoglobin/haptoglobin and subsequent breakdown of he. Binds hoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. After shedding, the soluble form (sCD163) may play an anti-inflammatory role.
- Source:Recombinant protein corresponding to aa86-365 from mouse Cd163, fused to His-Tag at N-terminal, expressed in Yeast.
- Molecular Weight:~32.2kD
- AA Sequence:VVCQQLGCPTSIKALGWANSSAGSGYIWMDKVSCTGNESALWDCKHDGWGKHNCTHEKDAGVTCSDGSNLEMRLVNSAGHRCLGRVEIKFQGKWGTVCDDNFSKDHASVICKQLGCGSAISFSGSAKLGAGSGPIWLDDLACNGNESALWDCKHRGWGKHNCDHAEDVGVICLEGADLSLRLVDGVSRCSGRLEVRFQGEWGTVCDDNWDLRDASVVCKQLGCPTAISAIGRVNASEGSGQIWLDNISCEGHEATLWECKHQEWGKHYCHHREDAGVTCS
- Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
仕様
- Size：20ug
- Source Antigen：Recombinant, Yeast
- Grade：Purified
- Purity：≥90% (SDS-PAGE)
- Form：Supplied as a liquid in Tris-HCl, pH 8.0, 1mM EDTA, 50% glycerol.
- Molecular Weight Non Ab：32.2
- Swiss Prot Number：Q2VLH6
- EU Commodity Code：30021019
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