Collagen is a fibrous protein found in the extracellular matrix and connective tissue. The most common form of collagen is type I and is most prevalent in bone, tendon and skin. It consists of 3 intertwined coiled subunits: 2 x α1 (I) chains and 1 x α2 (I) chain. Each chain contains 1050 amino acids wound tightly around one another in a characteristic right-handed triple helix. The triple-helical structure of collagen arises from unique abundance of the amino acids: glycine, proline, and hydroxyproline. These amino acids in collagen appear in a characteristic repeating motif Gly- X-Y, where X is usually proline and Y is usually hydroxyproline.
Smooth Coat Solution is a biocompatible complex of extracellular matrix binding solution that helps accelerate cell attachment in ≤ 7 minutes. SCS is a purified GMP grade solution in which cells proliferate and stabilize.
SCS is ideal for plate coating due to its unique viscosity. Its’ coating greatly enables cell migration on cultured plate surfaces. Perfect for establishing primary cell lines, it can increase endothelial cell attachment and survival in culture.
