TNFRSF18, also known as tumor necrosis factor receptor superfamily member 18 isoform 1, is receptor for TNFSF18. It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. TNFRSF18 mediated NF-kappa-B activation via the TRAF2/NIK pathway. Also, this protein reciprocally stimulated and activate intracellular signals regulating immune functions. In particular, GITR-driven T-cell co-stimulation was found to be the main mechanism by which the GITRL-GITR system contributes to tumor rejection and the development of autoimmune/inflammatory diseases.
Source:Recombinant protein corresponding to aa26-162 from human TNFRSF18, fused to hlgG-His-Tag at C-terminal, expressed in insect cell.
Molecular Weight:~41.6kD (376aa) 40-57KD (SDS-PAGE under reducing conditions.)
Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
仕様
Size：50ug
Source Antigen：Recombinant, human from insect cell line
Grade：Highly Purified
Purity：~95% (SDS-PAGE)
Form：Supplied as a liquid in PBS, pH 7.4, 10% glycerol.
