85-4642-13　Igfbp6, Recombinant, Mouse, aa26-238, His-Tag (Insulin-like Growth Factor-binding Protein 6) 50ug　369075

特徴

• Igfbp6, also known as insulin-like growth factor-binding protein 6, binds insulin-like growth factor 1(IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. It is a cysteine-rich protein with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. It plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence and IGF affinity.
• Source:Recombinant protein corresponding to aa26-238 from mouse Igfbp6, fused to His-Tag at C-terminal, expressed in insect cell.
• AA Sequence:ALAGCPGCGA GMQTGCRGGC VEEEDAGSPA DGCTEAGGCL RREGQPCGVY SPKCAPGLQC QPRENEEAPL RALLIGQGRC QRARGPSEET TKESKPQGGA SRSRDTNHRD RQKNPRTSAA PIRPNPVQDS EMGPCRRHLD SVLQQLQTEV FRGGARGLYV PNCDLRGFYR KQQCRSSQGN RRGPCWCVDP MGQPLPVSPD GQGSTQCSAR SSGLEHHHHH H
• Molecular Weight:~23.7kD (221aa) 28-40kD (SDS-PAGE under reducing conditions)
• Endotoxin:~1EU/1ug (LAL)
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.