CTLA4, also known as cytotoxic T-lymphocyte protein 4 isoform 1, is a type 1 membrane protein and a member of the immunoglobulin-superfamily. Besides, this protein contains an extra cellular domain, a transmembrane domain and a cytoplasmic tail. It is generally expressed with highest levels in lymphoid tissues. Also, it is similar to T-cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 and CD28 effectively regulate to T cell responses as opposing signals transmitted through two related cell-surface receptors.
Source:Recombinant protein corresponding to aa38-161 from mouse CTLA4, fused to hlgG-His-Tag at C-terminal, expressed in insect cell.
Molecular Weight:~40.6kD (363aa) 40-57KD (SDS-PAGE under reducing conditions.)
Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
仕様
Size：50ug
Source Antigen：Recombinant, mouse from insect cell line
Grade：Highly Purified
Purity：~95% (SDS-PAGE)
Form：Supplied as a liquid in PBS, pH 7.4, 10% glycerol.
