Cytomegalovirus gH Pentamer Complex comprises five viral proteins (gH, gL, UL128, UL130, and UL131A).
hCMV can cause serious morbidity/mortality in immune compromised individuals such as transplant recipients and HIV patients, and congenital HCMV infection can lead to birth defects. The Cytomegalovirus gH Pentamer Complex is expressed on all wildtype hCMV strains but is notably missing from laboratory strains such as AD169 (1).
This has placed severe limitations on vaccine development. Receptor-mediated viral entry into endothelial cells requires a functional gH pentameric complex, and this complex is one of the primary targets for antiviral antibodies in infected individuals. This new recombinant hCMV gH complex will be key to enabling essential basic and applied research. In addition, the gH complex is expected to provide the basis for a new generation of IVD tests.
The native-like Cytomegalovirus gH Pentamer Complex is produced in human cells to ensure that all proteins are properly folded and possess their native glycosylation pattern. The presence of all five proteins in the purified complex is confirmed by mass spectrometry.
Recombinant protein corresponding to human Cytomegalovirus gH Pentamer Complex, strain VR1814 with a His-Tag, expressed in HEK293 cells.
Storage and Stability:Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
