85-4640-45　Y-27632 Dihydrochloride 50mg　CAS No:129830-38-2　366915

特徴

• Y-27632 is a selective inhibitor of Rho-associated coiled-coil forming protein serine/threonine kinase (ROCK) family of protein kinases that selectively competes with ATP for binding to the catalytic site. It is reported to diminish dissociation-induced apoptosis, increase cloning efficiency, and facilitate subcloning after gene transfer in human embryonic stem cells (hES).
• Synonyms:trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide Dihydrochloride; (+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide Dihydrochloride; (+)-trans-N-(4-Pyridyl)-4-[(R)-1-aminoethyl]cyclohexanecarboxamide Dihydrochloride
• Molecular Formula:C₁₄H₂₁N₃O•2(HCl)
• Molecular Weight:320.3
• Appearance:Crystalline solid
• Purity:≥98%
• Melting Point:>260°C (dec.)
• Solubility:Methanol (Slightly); Soluble in organic solvents such as ethanol and DMSO. DMSO up to 90mM. For solvent free solutions, so;luble in PBS, pH7.2 up to 30mM.
• Storage and Stability:Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with ethanol or DMSO.. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.