85-4639-63　Alpelisib, Free Base, 99+% 5mg　CAS No:1217486-61-7　366863

特徴

• Alpelisib, also known as BYL719, is a potent and selective phosphatidylinositol-3 kinase [alpha] inhibitor. It inhibited P110[alpha], p110[beta], p110[delta], and p110[gamma] with IC50 values of 5nM, 1.2uM, 0.29uM and 0.25uM, respectively, in biochemical assays. It inhibited the Akt phosphorylation with IC50 values of 74 nM in Rat1-myr-p110[alpha] cells, 2.2uM in Rat1-myr-p110[beta] cells, and 1.2uM in Rat1-myr-p110[delta] cells. Furet P., et al. "Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation." Bioorg. Med. Chem. Lett. 23: 3741-3748 (2013).
• Synonyms:BYL-719; NVP-BYL719; (S)-Pyrrolidine-1,2-dicarboxylic Acid 2-Amide 1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-pyridin-4-yl]thiazol-2-yl]amide; (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide
• Molecular Formula:C19H22F3N5O2S
• Molecular Weight:441.47
• Purity:≥99% (HPLC)≥99% (TLC)
• Appearance:White to off-white crystalline solid
• Melting Point:198.5-200°C
• Storage and Stability:Store at -20°C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.