Hepatitis C Virus is a single-stranded, positive RNA flavivirus that causes severe liver disease. Initial and early chronic infection is usually mild or asymptomatic, but often progresses to liver disease, cirrhosis, liver failure and liver cancer. Transmission is primarily by blood-to-blood contact associated with intravenous drug use or transfusions, affecting an estimated 170 million people annually.
The HCV core protein is a structural protein that forms an icosahedral protective shell surrounding the viral RNA. The mature viral particle is further encased in a lipid (fatty) envelope of cellular origin into which viral glycoproteins E1 and E2 are embedded. It is highly immunogenic and as such a good candidate for HCV detection.
Recombinant protein corresponding to HCV core expressed in E. coli.
Molecular Weight:~16.8kD
Activity:Binds HCV positive serum antibodies
Applications:Suitable for use in ELISA, Western Blot and Lateral Flow. Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
仕様
Size：1mg
Source Antigen：Recombinant, E. coli
Grade：Highly Purified
Purity：≥95% (SDS-PAGE)
Form：Supplied as a lyophilized powder in PBS, pH 7.4. No preservative added.
