85-4621-30　［取扱停止］CXCL16, Recombinant, Mouse (C-X-C Motif Chemokine 16, Small-Inducible Cytokine B16, Transmembrane Chemokine CXCL16) 5ug　360062

特徴

• Mouse CXCL16 is a nonELR motif including CXC chemokine with a transmembrane domain. CXCL16 induces a strong chemotactic response and calcium mobilization. CXCL16 also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in atherogenesis. Mouse CXCL16 is generated by dendritic cells in lymphoid organ T cell zones and by cells in the splenic red pulp both as membrane bound and soluble forms. CXCL16 is expressed in the spleen, lymph nodes, Peyer patches non-lymphoid tissues (e.g. lung, kidney, small intestine, thymus). It is weakly expressed in heart and liver and not expressed in brain and purified B- and T-cells. CXCL16 deficiency is linked to breast cancer progression and is involved in immunological liver injury (by regulating T lymphocyte infiltration). CXCL16 has a distinctive role in the maintenance of cardiac allograft tolerance mediated by natural killer T cells, and in the production of IFN-gamma by NKT cells and promotion of Th1-inclined immune responses mediated by NKT cells.
• Source:Recombinant protein corresponding to 88aa from mouse CXCL16, expressed in E. coli.
• Molecular Weight:~9.9kD (88aa)
• Applications:Suitable for use in SDS-PAGE. Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Biological Activity:Determined by its ability to chemoattract murine lymphocytes using a concentration of 20-1000ng/ml, corresponding to a specific activity of ＞100IU/mg.
• Endotoxin:<1EU/mg (LAL)
• AA Sequence:NQGSVAGSCS CDRTISSGTQ IPQGTLDHIR KYLKAFHRCP FFIRFQLQSK SVCGGSQDQW VRELVDCFER KECGTGHGKS FHHQKHLP
• Storage and Stability:Lyophilized powder may be stored at -20°C. Reconstitute with sterile dH2O, 0.1% BSA. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.