3-isobutyl-1-methylxanthine (IBMX) is a nonselective inhibitor of cAMP and cGMP phosphodiesterases (PDEs). Research studies show that IBMX inhibits many members of the PDE family, with the exceptions of PDE8A, PDE8B, and PDE9 (1-4). Treatment of cells with IBMX promotes accumulation of cAMP and cGMP, which leads to activation of cyclic- nucleotide- regulated protein kinases (5,6). Additional research indicates that IBMX can promote neuronal progenitor cell maturation in vitro (7).
Formula:C10H14N4O2
Solubility:Soluble in DMSO up to ~222mg/ml (1M) with warming. Soluble in DMF or ethanol at 5mg/ml.
Molecular Weight:222.30g/mol
Storage and Stability:Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
仕様
Size：50mg
Grade：Highly Purified
Purity：Highly Purified (~98%)
Form：Supplied as a lyophilized powder. For a 250mM stock, reconstitute the 50mg in 899.7ul DMSO.
