85-4493-85　TSC22D3, Recombinant, Human, aa1-134, His-Tag (TSC22 Domain family protein 3, DIP, DSIPI, GILZ, hDIP, TSC-22R) 250ug　351545

特徴

• TSC22 domain family protein 3, also known as TSC22D3, protects T-cells from IL2 deprivation- induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, TSC22D3 plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, TSC22D3 inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities.
• Source:Recombinant protein corresponding to aa1-134 from human TSC22D3, fused to His-tag at N-terminal expressed in E. coli.
• Molecular Weight:~17.2kD(157aa)
• AA Sequence:MGSSHHHHHH SSGLVPRGSH MGSMNTEMYQ TPMEVAVYQL HNFSISFFSS LLGGDVVSVK LDNSASGASV VAIDNKIEQA MDLVKNHLMY AVREEVEILK EQIRELVEKN SQLERENTLL KTLASPEQLE KFQSCLSPEE PAPESPQVPE APGGSAV
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.