85-4493-75　TPM3, Recombinant, Human, aa1-248, His-Tag(Tropomyosin alpha-3 chain, Hscp30, NEM1, OK/SW-cl.5, TM-5, TM3, TM30 TM30nm, TPMsk, TRK) 250ug　351540

特徴

• Tropomyosin alpha-3 chain, also known as TPM3, is member of the tropomyosin family of actin- binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non- muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer.
• Source:Recombinant protein corresponding to aa1-248 from human TPM3, fused to His-tag at N-terminal expressed in E. coli.
• Molecular Weight:~31.6kD (272aa)
• AA Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMAGITT IEAVKRKIQV LQQQADDAEE RAERLQREVE GERRAREQAE AEVASLNRRI QLVEEELDRA QERLATALQK LEEAEKAADE SERGMKVIEN RALKDEEKME LQEIQLKEAK HIAEEADRKY EEVARKLVII EGDLERTEER AELAESRCRE MDEQIRLMDQ NLKCLSAAEE KYSQKEDKYE EEIKILTDKL KEAETRAEFA ERSVAKLEKT IDDLEDKLKC TKEEHLCTQR MLDQTLLDLN EM
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.