85-4491-01　NME1, Recombinant, Human, aa1-152 (Non-metastatic cells 1, Nucleoside diphosphate Kinase A, NDP Kinase A, AWD, GAAD, NB, NBS, NDPK-A, NM23, NM23-H1) 100ug　351392

特徴

• Non-metastatic cells 1 (NME1), also known as NM23-H1, originally identified as a candidate metastasis suppressor gene. NME1 is expressed in different tumor types where their levels have been alternatively associated with reduced or increased metastatic potential. Reductions in NME1 expression have been significantly associated with aggressive behavior in melanoma, breast, colon, and gastric carcinomas. On the contrary, high levels of NME1 gene expression are noted in the advanced stage of thyroid carcinomas
• Source:Recombinant protein corresponding to aa1-152 from human NME1, expressed in E. coli.
• Molecular Weight:~17.1kD (152aa)
• Specific Activity:>1200units/mg, and is defined as the amount of enzyme that convert 1umole each of ATP and TDP to ADP and TTP/minute at pH 7.5 at 25°C in a couple system with PK/LDH.
• AA Sequence:MANCERTFIA IKPDGVQRGL VGEIIKRFEQ KGFRLVGLKF MQASEDLLKE HYVDLKDRPF FAGLVKYMHS GPVVAMVWEG LNVVKTGRVM LGETNPADSK PGTIRGDFCI QVGRNIIHGS DSVESAEKEI GLWFHPEELV DYTSCAQNWI YE
• Endotoxin: ~1EU/1ug (LAL)
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.