85-4471-28　PRL-3 Inhibitor (BR-1, P0108, Phosphatase of Regenerating Liver 3 Inhibitor, PTP4A3 Inhibitor) 25mg　CAS No:893449-38-2　349626

特徴

• Phosphatase of regenerating liver 3 (PRL-3, also known as PTP4A3) plays critical roles in cell proliferation, motility, and invasion, and thus contributes to cancer metastasis. PRL-3 inhibitor is a cell-permeable benzylidene rhodamine that inhibits PRL-3 (IC50=900nM for human PRL-3 in vitro), with minimal activity against other phosphatases. It reduces the invasion of mouse melanoma B16F10 cells in a cell-based assay. PRL-3 inhibitor has been used to elucidate the actions of this enzyme, demonstrating that it dephosphorylates Tyr783 on integrin beta1 and modulates VEGF-mediated endothelial cell migration. It dose-dependently inhibits the growth and triggers apoptosis in cancer cell lines.
• Molecular Formula:C17H11Br2NO2S2
• Solubility:Organic solvents DMSO and dimethyl formamide (~16mg/ml), which should be purged with an inert gas. Sparingly soluble in aqueous buffers.
• Molecular Weight:485.2
• Lambda max:273, 384nm
• Storage and Stability:Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.