85-4454-97　［取扱停止］Neuroserpin, active (SERPINI1), Recombinant, Human 250ug　348181

特徴

• Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.
• Biological Activity:Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using rat C6 cells is less than 0.5ug/ml, corresponding to a specific activity of > 2000 IU/mg.
• Sequence:TGATFPEEAI ADLSVNMYNR LRATGEDENI LFSPLSIALA MGMMELGAQGSTQKEIRHSM GYDSLKNGEE FSFLKEFSNM VTAKESQYVM KIANSLFVQNGFHVNEEFLQ MMKKYFNAAV NHVDFSQNVA VANYINKWVE NNTNNLVKDLVSPRDFDAAT YLALINAVYF KGNWKSQFRP ENTRTFSFTK DDESEVQIPMMYQQGEFYYG EFSDGSNEAG GIYQVLEIPY EGDEISMMLV LSRQEVPLATLEPLVKAQLV EEWANSVKKQ KVEVYLPRFT VEQEIDLKDV LKALGITEIFIKDANLTGLS DNKEIFLSKA IHKSFLEVNE EGSEAAAVSG MIAISRMAVLYPQVIVDHPF FFLIRNRRTG TILFMGRVMH PETMNTSGHD
• Molecular Weight:44.7kD
• PubMed ID:9070919; 14702039; 17974005; 15489334; 10517635
• Gene Name:SERPINI1,PI12
• Swiss Prot:Q99574
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.