85-4454-81　［取扱停止］MHC class I polypeptide-related sequence A, active (MICA), Recombinant, Human 50ug　348176

特徴

• Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. {ECO:0000269|PubMed:10426993, ECO:0000269|PubMed:11224526, ECO:0000269|PubMed:11491531, ECO:0000269|PubMed:11777960, ECO:0000269|PubMed:9497295}.
• Biological Activity:Fully biologically active when compared to standard. The specific activity is determined by binding MICA antibody in ELISA.
• Sequence:EPHSLRYNLT VLSWDGSVQS GFLAEVHLDG QPFLRYDRQK CRAKPQGQWA EDVLGNKTWD RETRDLTGNG KDLRMTLAHI KDQKEGLHSL QEIRVCEIHE DNSTRSSQHF YYDGELFLSQ NLETEEWTVP QSSRAQTLAM NVRNFLKEDA MKTKTHYHAM HADCLQELRR YLESGVVLRR TVPPMVNVTR SEASEGNITV TCRASSFYPR NIILTWRQDG VSLSHDTQQW GDVLPDGNGT YQTWVATRIC RGEEQRFTCY MEHSGNHSTH PVPSGKVLVL QSHW
• Molecular Weight:32.8kD
• PubMed ID:8022771; 8613147; 14574404; 15489334; 7927538; 8781120; 10e331160; 10e380703; 10e369920; 15104678; 10e380704; 11556982; 11841487; 10746789; 12074712; 16634869; 10e369917; 12542746; 8901601; 9396860; 9497295; 10e323458; 10e363723; 10e359807; 10426993; 10426994; 10691930; 11053635; 11777960; 19793804; 10752636; 11485740; 11491531; 11224526; 12466900; 12370336; 12384702; 11830641; 12902493; 15995699; 16750166; 17495932; 17565371; 18287244; 18202175; 10e367903; 11323699
• Gene Name:MICA, PERB11.1
• Swiss Prot:Q29983
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.