Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.
Full-length recpmbinant protein corresponding to aa25-182 from human MANF, expressed in E. coli. Swiss/UniProt: P55145
Storage and Stability:Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
仕様
Size：5ug
Source Antigen：Recombinant, Human, E. coli
Grade：Highly Purified
Purity：≥95% as determined by SDS-PAGE and HPLC.
Form：Supplied as a lyophilized powder from PBS, pH 7.4. Reconstitute with sterile dH2O to a concentration of 0.1-1mg/ml.
