85-4453-79　［取扱停止］Interleukin-36 receptor antagonist, active (IL36RN), Recombinant, Mouse 100ug　348140

特徴

• Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2/IL-36R and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. {ECO:0000269|PubMed:17908936, ECO:0000269|PubMed:18284608, ECO:0000269|PubMed:21860022, ECO:0000269|PubMed:21965679}.
• Biological Activity:Measured by its ability to inhibit IL-36γ induced IL-6 production by human PBMCs.
• Sequence:VLSGALCFRM KDSALKVLYL HNNQLLAGGL HAEKVIKGEE ISVVPNRALD ASLSPVILGV QGGSQCLSCG TEKGPILKLE PVNIMELYLG AKESKSFTFY RRDMGLTSSF ESAAYPGWFL CTSPEADQPV RLTQIPEDPA WDAPITDFYF QQCD
• Molecular Weight:16.9kD
• PubMed ID:11093146; 10744718; 11466363; 16141072; 17908936; 18284608; 21860022; 21965679; 12974628
• Gene Name:IL36RN, Fil1d, Il1f5, Il1h3, Il1hy1
• Swiss Prot:Q9QYY1
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.