85-4453-76　［取扱停止］Interleukin-36 receptor antagonist, active (IL36RN), Recombinant, Human 250ug　348139

特徴

• Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. {ECO:0000269|PubMed:11466363, ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:23147407}.
• Biological Activity:Fully biologically active when compared to standard. The ED50 as determined by inhibiting IL-36 beta induced IL-8 secretion by human preadipocytes is less than 1.0ug/ml, corresponding to a specific activity of ＞ 1000 IU/mg in the presence of 20ng/ml of recombinant human IL-36 beta.
• Sequence:VLSGALCFRM KDSALKVLYL HNNQLLAGGL HAGKVIKGEE ISVVPNRWLD ASLSPVILGV QGGSQCLSCG VGQEPTLTLE PVNIMELYLG AKESKSFTFY RRDMGLTSSF ESAAYPGWFL CTVPEADQPV RLTQLPENGG WNAPITDFYF QQCD
• Molecular Weight:16.8kD
• PubMed ID:10625660; 10512743; 11093146; 11466363; 10860666; 11991722; 12975309; 14702039; 15815621; 15489334; 21965679; 23147407; 21839423; 21848462; 22903787
• Gene Name:IL36RN,FIL1D,IL1F5,IL1HY1,IL1L1,IL1RP3,UNQ1896/PRO4342
• Swiss Prot:Q9UBH0
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.