85-4450-57　［取扱停止］Fibroblast Growth Factor 21, active (FGF21), Recombinant, Human 25ug　348045

特徴

• Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB.
• Biological Activity:Fully biologically active when compared to standard. The ED50 as determined by thymidine uptake assay using FGF-receptors transfected BaF3 cells is less than 0.5ug/ml, corresponding to a specific activity of ＞ 2.0x10e3 IU/mg in the presence of 5ug/ml of rMuKlotho-β and 10ug/ml of heparin.
• Sequence:HPIPDSSPLL QFGGQVRQRY LYTDDAQQTE AHLEIREDGT VGGAADQSPE SLLQLKALKP GVIQILGVKT SRFLCQRPDG ALYGSLHFDP EACSFRELLL EDGYNVYQSE AHGLPLHLPG NKSPHRDPAP RGPARFLPLP GLPPALPEPP GILAPQPPDV GSSDPLSMVG PSQGRSPSYA S
• Molecular Weight:19.4kD
• PubMed ID:10858549; 12975309; 15489334; 15340161; 15902306; 17623664; 18829467; 19117008; 20094046
• Gene Name:FGF21, UNQ3115/PRO10196
• Swiss Prot:Q9NSA1
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.