Agouti-Related Protein (AGRP), first identified by Ollman and co-workers is a potent antagonist of MC3-R and MC4-R and is an integral component in the metabolic processes that regulate feeding behavior and body weight. Present in the hypothalamus, AGRP levels are elevated in obese males (Katsuki et al, 2001). has not only identified and synthesized several AGRP fragments that are as potent inhibitors of MC3-R and MC4-R as the parent molecule, but also the intact protein, AGRP Form C (Jimenez et al, 1999). Powerful immunological tools have been developed from these compounds that enable researchers to probe the metabolic processes that lead to obesity.
Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
