An acute-phase plasma protein found in human plasma at 100-300mg/100ml. Binds hemoglobin, thus preventing loss of iron through the kidneys. Humans are polymorphic for haptoglobin, with three major phenotypes. Hp 1-1 is the most common, and the most effective in binding free hemoglobin. Hp 2-2 is the least effective. This functional difference may be associated with the frequency and severity of epilepsy attacks, as researchers have found a correlation between recurring seizures and the Hp 2-2 phenotype. Hp 2-2 is associated with renal failure, familial epilepsy, hypertension, atherosclerosis and coronary heart diseases. Individuals who are phenotype 2-2 have the lowest concentration of haptoglobin in plasma.
Source:Native Haptoglobin, from human plasma
Purity:≥95% (SDS-PAGE). No visible alpha-1 light chain.
Molecular Weight::170,000-900,000
Extinction Coefficient:1.20
Storage and Stability:Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
仕様
Size：1mg
Source Antigen：Human plasma
Grade：Highly Purified
Purity：≥95% (SDS-PAGE). No visible alpha-1 light chain.
