Sodium aescinate is used as a vasoactive drug in clinical treatment. Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway. Sodium aescinate can block signals transiting to downstream molecules AKT, ERK, inhibit the proliferation of breast cancer cell MCF-7 cell apoptosis and induced cell apoptosis by suppressing the activation of SRC[3]. Sodium aescinate may effectively controls and improves wound healing in diabetic rats via its anti-inflammatory and antioxidant activities[1]
Sodium aescinate treatment can alleviate the symptom of polycystic ovary syndrome (PCOS) in rat model through regulating the PI3K/Akt/GSK3-β pathway[4].
Synonyms:Escin monosodium salt
Botanical Source:Aesculi semen
Molecular Formula:C55H86NaO23
Molecular Weight:1124.23
Appearance:White to off-white powder
Purity (HPLC-DAD or/and HPLC-ELSD):≥90%
Identification Method:Mass, NMR
Solubility:DMSO (10mg/ml)
Storage and Stability:Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
