85-4434-07　Ginsenoside CK 10mg　CAS No:39262-14-1　300341

特徴

• Ginsenoside compound K (C-K) is a metabolite of the protopanaxadiol-type saponins of Panax ginseng C.A. Meyer (Araliaceae), has long been used to treat against the development of cancer, inflammation, allergies, and diabetes; C-K acts as a unique HUVEC migration inhibitor by regulating MMP expression, as well as the activity of SPHK1 and its related sphingolipid metabolites.[1]Ginsenoside compound K, the intestinal metabolite of ginseng saponin, has various chemopreventive and chemotherapeutic activities, including anti-tumor activity; C-K suppresses the activation of the NF-κB pathway, may become a potential cytotoxic drug in the prevention and treatment of hepatocellular carcinoma( HCC).[2]Ginsenoside compound K shows significant anti-proliferative effects and pro-apoptotic effects in HCT-116 and SW-480 cells at concentrations of 30-50 uM, suggests that C-K could be potentially effective anti-colorectal cancer agent.[3]Ginsenoside CK has anti-cancer effect on NPC cells, C-K-induced apoptosis of HK-1 cells was mediated by the mitochondrial pathway and could significantly inhibit tumor growth in vivo.[4]
• Synonyms:(3β,12β)-3,12-Dihydroxydammar-24-en-20-yl β-D-Glucopyranoside; 20(S)-Protopanaxadiol 20-O-D-Glucopyranoside; 20(S)-Protopanaxadiol 20-O-β-D-Glucopyranoside; 20-O-β-D-Glucopyranosyl-20(S)-protopanaxadiol; 20-O-β-Glucopyranosyl-20(S)-protopanaxadiol; 3-O-Deglucosylginsenoside F2; Compound K; Ginsenoside IH901; Ginsenoside K; Ginsenoside M1; Ginsenoside Compound K; Ginsenoside Metabolite M1; IH 901; LCHK 168; Protopanaxadiol 20-O-Glucoside
• Botanical Source:Prod. from saponins of Gynostemma pentaphyllum by endogenous glycosidases
• Molecular Formula:C₃₆H₆₂O₈
• Molecular Weight:622.87
• Appearance:White powder
• Purity:≥98% ( HPLC-DAD or/and HPLC-ELSD)
• Identification (Mass, NMR):Conforms to structure
• Melting Point:>149°C (dec.)
• Solubility:Methanol (Slightly), Pyridine (Slightly)
• Storage and Stability:Store at -20°C. Hygroscopic., Under inert atmosphere. Store in a well closed container, protected from air and light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.