alpha Synuclein is a member of a family of small, highly conserved proteins, including synuclein-alpha, -beta, and -gamma, and synoretin. These proteins are localized predominantly in the brain, concentrated in presynaptic nerve terminals. Synuclein-alpha is normally a soluble protein. Abnormal synuclein-alpha forms filamentous inclusions (Lewy bodies and Lewy neurites) in several neurodegenerative diseases, including Parkinson's disease (PD), dementia with Lewy bodies, and Alzheimer's disease. It is a major component of intracellular inclusions in sporadic PD. Mutations in the synuclein-alpha gene (A53T and A30P) have been reported in several families with autosomal dominant Parkinsonism.
Source:Recombinant protein corresponding to human alpha Synuclein, a single, non-glycosylated polypeptide chain of 140aa, expressed in E. coli.
Molecular Weight:~14.4kD
AA Sequence:MDVFMKGLSK/ AKEGVVAAAE/ KTKQGVAEAA/ GKTKEGVLYV/ GSKTKEGVVH/GVATVAEKTK/ EQVTNVGGAV/VTGVTAVAQK/TVEGAGSIAA/ ATGFVKKDQL/ GKNEEGAPQE/ GILEDMPVDP/DNEAYEMPSE/EGYQDYEPEA
Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
仕様
Size：20ug
Source Antigen：Recombinant, E. coli
Grade：Highly Purified
Purity：~95% (RP-HPLC, SDS-PAGE)
Form：Supplied as a liquid in 20mM Tris-HCl, pH 7.5, 0.1M sodium chloride, 1mM MgCl2.
