85-4423-95　［取扱停止］Galectin-7, Recombinant, Human (LGAS7) 10ug　299395

特徴

• Galectin-7 belongs to the prototypical Galectins containing a single CRD, which is initially identified in human epidermis as a monomer. The Galectin-7 expression is induced by tumor suppressor protein p53 and associated with apoptosis. Galectin-7 is a pro-apoptotic protein which functions intracellularlly upstream of JNK activation and mitochondrial cytochrome c release. The correlation of Galectin-7 with the UV-induced apoptosis of keratinocytes presents a critical mechanism in the maintenance of epidermal homeostasis. Human Galectin-7 is localized in both nucleus and cytoplasm.
• Source:Recombinant protein corresponding to human LGAS7, a single, non-glycosylated, polypeptide chain containing 135aa, expressed in E. coli.
• Molecular Weight:~15kD
• Biological Activity:Determined by hemagglutination test, the ED50 is 0.75-3ug/ml.
• AA Sequence: The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Asn-Val-Pro-His.
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.