85-4423-30　［取扱停止］Cathepsin D, Recombinant, Human 2ug　299330

特徴

• Cathepsin D is a lysosomal aspartic protease of the pepsin family. Human Cathepsin D is synthesized as a precursor protein, consisting of a signal peptide (residues 1-18), a propeptide (residues 19-64), and a mature chain (residues 65-412). The mature chain can be processed further to the light (residues 65-161) and heavy (residues 169-412) chains. It is an estrogen-regulated lysosomal protease that has been suggested to facilitate cancer cell migration and invasion by digesting the basement membrane, extracellular matrix, and xonnective tissue. Because of its mitogenic and proteolytic activities, it has been implicated as a prognostic marker in many tumor types. It could also play a role in Alzheimer's Disease.
• Source:Recombinant protein corresponding to full length human Cathepsin D, expressed in E. coli.
• Molecular Weight:~48kD (SDS-PAGE)
• AA Sequence:mqpssllpla lcllaapasa lvriplhkft sirrtmsevg gsvedliakg pvskysqavp avtegpipev lknymdaqyy geigigtppq cftvvfdtgs snlwvpsihc klldiacwih hkynsdksst yvkngtsfdi hygsgslsgy lsqdtvsvpc qsassasalg gvkverqvfg eatkqpgitf iaakfdgilg mayprisvnn vlpvfdnlmq qklvdqnifs fylsrdpdaq pggelmlggt dskyykgsls ylnvtrkayw qvhldqveva sgltlckegc eaivdtgtsl mvgpvdevre lqkaigavpl iqgeymipce kvstlpaitl klggkgykls pedytlkvsq agktlclsgf mgmdipppsg plwilgdvfi gryytvfdrd nnrvgfaeaa rl
• Applications:Suitable for use in ELISA, Western Blot and Inhibition Assays. Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.