85-4419-88 WISP1, Recombinant, Human (CCN4, WNT1-Inducible-Signaling Pathway Protein 1, CCN Family Member 4, Wnt-1-Induced Secreted Protein) 10ug 298315
85-4419-88 WISP1, Recombinant, Human (CCN4, WNT1-Inducible-Signaling Pathway Protein 1, CCN Family Member 4, Wnt-1-Induced Secreted Protein) 10ug 298315
Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan.
Source:Recombinant protein corresponding to human WISP1, fused to Fc-domain of human IgG, expressed in insect cell line.
Molecular Weight:~67.3kD
Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
仕様
Size：10ug
Source Antigen：Recombinant, Insect cell line
Grade：Highly Purified
Purity：~90% (SDS-PAGE)
Form：Supplied as a lyophilized powder in 0.1M glycine HCl, pH 3.0. No preservative added. Reconstitute with sterile ddH2O.
