85-4360-97　Ribavirin 250g　CAS No:36791-04-5　296417

特徴

• Ribavirin is a nucleoside analog that inhibits the replication of both DNA and RNA viruses, including influenza type A and type B. Ribavirin, as ribavirin 5’-phosphate, affects virus-infected cells primarily by inhibiting the enzyme inosine 5’-monophosphate (IMP) dehydrogenase. It potently suppresses eIF4E-mediated oncogenic transformation of murine cells in vitro, of tumor growth of a mouse model of eIF4E-dependent human squamous cell carcinoma in vivo, and of colony formation of eIF4E-dependent acute myelogenous leukemia cells derived from human patients.
• Ribavirin is a so-called antimetabolite, i.e. a drug that is chemically similar to naturally occurring metabolites but interfering with normal metabolic pathways. It is an antiviral nucleoside analog to the natural ribonucleoside guanosine (1). Ribavirin is a broad-spectrum antiviral drug, belonging to the group of  inosine monophosphate (IMP) dehydrogenase inhibitors (2)
•  Acting as a virostatic agent, ribavirin is used as an effective drug against respiratory syncytial virus (RSV), herpes viruses, influenza viruses type A and B, Hantaan virus, hepatitis C virus, adenoviruses, flavi viruses, reo viruses, and others.
• Synonym:1-b-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
• Molecular Formula:C8H12N4O5
• Molecular Weight:244.2
• Form:White to off-white powder
• Specific Optical Rotation ([α]20D:-37.0 - -33.5°
• Identity (IR):Confoms to structure
• pH:4.0 - 6.5
• Loss on Drying:≤0.5%
• Residue on Ignition (sulfated):≤0.5%
• Heavy Metals (Pb):≤10ppm
• Storage and Stability:Store at -20°C Stable for 6 months after receipt at -20°C.