85-4351-53　5-Hydroxymethylcytidine 5mg　CAS No:19235-17-7　296186

特徴

• 5-Hydroxymethylcytosine is a DNA pyrimidine nitrogen base. It is formed from the DNA base cytosine by adding a methyl group and then a hydroxy group. It is important in epigenetics, because the hydroxymethyl group on the cytosine can possibly switch a gene on and off. It was first seen in bacteriophages in 1952.[1][2] However, in 2009 it was found to be abundant in human and mouse brains,[3] as well as in embryonic stem cells.[4] In mammals, it can be generated by oxidation of 5-methylcytosine, a reaction mediated by the Tet family of enzymes. 5-Hydroxymethylcytidine is a product in DNA hydroxymethylation. The concentrations of 5-Hydroxymethylcytidine in the brain were used to study Alzheimer’s disease.
• Identity (1H NMR):Conforms to structure
• Melting Point:>210°C (dec.)
• Solubility:DMSO (Slightly), Water (Slightly)
• Density:1.92±0.1g/cm3 (20ºC 760Torr)
• Storage and Stability:Lyophilized powder may be stored at 4°C. Stable for 6 months after receipt. Hygroscopic. Keep tightly closed and desiccated under inert atmosphere.