85-4346-76　［受注停止］Diadenosine Pentaphosphate Pentasodium Salt 2mg　CAS No:4097-04-5　296060

特徴

• Diadenosine pentaphosphate pentaammonium is an endogenous vasoactive purine dinucleotide which has been isolated from thrombocytes. Diadenosine polyphosphates (ApnA, n=2–7) have been identified as constituents of secretory vesicles such as in platelets, chromaffin cells, Torpedo synaptic terminals and brain synaptosomes. P1,P5-Di(adenosine-5′) pentaphosphate (Ap5A) is a diadenosine polyphosphate, which has a tail-to-tail dimer structure. Ap5A is synthesized in a twostep process involving the formation of adenosine 5′-tetraphosphate (P4A) from the ATP and trimeta-phosphate (P3). In the second step, P4A is converted to Ap5A. The synthesis of Ap5A requires a pH optimum in the range of 7.5 to 8.5 and is modulated by metal ions.
• Applications:
• an adenylate kinase (AK) inhibitor in: sarcoma osteogenic (Saos-2) cells
• mitochondrial lysates during ATP synthesis
• tetramethylrhodamine methyl ester (TMRM) based membrane potential assay
• chromoplasts
• Synonyms:P1,P5-Di(adenosine-5') pentaphosphate pentasodium salt; A(5′)P5(5′)A, Diadenosine pentaphosphate pentasodium salt
• Molecular Formula:C20H29N10O22P5·5Na
• Molecular Weight:1026.28
• Purity:≥95% (HPLC)
• Appearance:White to off-white powder
• Solubility:Water: 50mg/ml
• Storage and Stability:Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.