85-4340-99　4-Deoxyuridine (Zebularine) 1g　CAS No:3690-10-6　295906

特徴

• A cytidine analogue and inhibitor of DNA methyl transferases (DNMTs) with anti-cancer activity. This stable, hydrophilic compound forms covalent complexes between DNMT and zebularine-substrate DNA. It causes DNA lesions that block replication and cause replication fork collapse, leading to the formation of DNA double-strand breaks. It was also shown that zebularine-induced DNA methylation decrease in the IL-1β promoter region and disrupts molecular mechanisms of neuroinflammation. Moreover, this molecule down-regulates the DNA-methylation profile in the pluripotency genes’ promoters, which leads to improved development of somatic cell nuclear transfer (SCNT) embryos.
• Synonyms:1-β-D-Ribofuranosyl-2(1H)-pyrimidinone; 4-Deoxyuridine; NSC 309132; Pyrimidin-2-one β-D-Ribofuranoside; Zebularine
• Molecular Formula:C₉H₁₂N₂O₅
• Molecular Weight:228.21
• Purity:≥98%
• Appearance:White to off-white powder
• 1H NMR:Conforms to reference
• Melting Point:>150˚C (dec.)
• Solubility:DMSO (Slightly), Methanol (Slightly), Water (100mM)
• Storage and Stability:Store at 4°C. Hygroscopic, under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.