85-4313-41　S-Adenosyl-L-methionine Disulfate Tosylate (doMet SAM Disulfate p-toluenesulfonate, SAMe) 100g　CAS No:97540-22-2,Free Base: 28594-13-0　295234

特徴

• A methyl donor and a cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. SAM is anti-apoptotic in normal hepatocytes and normal colon epithelial cells but pro-apoptotic in liver human hepatocellular carcinoma (HCC), HepG2 cells and colon cancer cells.
• Synonyms:Ademetionine Disulfate Tosylate; 4-Methylbenzenesulfonate (salt) Sulfate (salt) (1:1:1:1) (9CI); FO 1561; S-Adenosyl-L-methionine Disulfate Tosylate; 5'-[[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5'-deoxyadenosine Sulfate 4-Methylbenzenesulfonate Sulfate; (3S)-5'-[(3-Amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine Sulfate 4-Methylbenzenesulfonate; 5'-[[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5'-deoxyadenosine Sulfate 4-methylbenzenesulfonate Sulfate
• Molecular Formula:C₂₂H₃₄N₆O₁₆S₄
• Molecular Weight:766.8
• Purity:≥95%
• Appearance:White to off-white crystalline powder
• Melting Point:>122°C (dec.) (lit)
• Heavy Metals:≤0.001%
• Water Content (Karl Fischer):≤2%
• Storage and Stability:Store at 4ºC. Stable for 6 months after receipt.
• Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
• Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.