85-4310-91　9-(b-D-Arabinofuranosyl)guanine 250mg　CAS No:38819-10-2　295176

特徴

• Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine (Item No. 20248).1,2 Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated into the DNA.3,1 Ara-G inhibits DNA replication by 92% after 30 minutes when used at a concentration of 50 µM in CEM cells, which are used as a model for human T lymphoblasts.1 It also halts the cell cycle at the sub-G1 phase and induces apoptosis in CEM cells.3 Syngeneic bone marrow containing 6C3HED tumor cells treated with ara-G (100 mM) ex vivo prior to transplantation increases survival of lethally irradiated mice and induces reconstitution of lymphoid, myeloid, and erythroid cell linages.4
• Synonyms:2-Amino-9-β-D-arabinofuranosyl-1,9-dihydro-6H-purin-6-one; 2-Amino-6-hydroxy-9-(β-D-arabinofuranosyl)purine; 9-β-D-Arabinofuranosylguanine; Arabinoguanosine; Araguanosine; Guanine arabinoside; NSC 76352; ara-Guanosine
• Molecular Formula:C10H13N5O5
• Molecular Weight:283.24
• Appearance:White to off-white powder
• Purity:≥98%
• Melting Point:>245°C (dec.)
• Solubility:Aqueous Base (Slightly, Sonicated), DMSO (Slightly)
• Storage and Stability:Store at -20°C under inert atmosphere. Hygroscopic. For maximum recovery of product, centrifuge the original vial prior to removing the cap.