85-4253-93　L-Iduronic acid 10mg　CAS No:2073-35-0　293766

特徴

• L-Iduronic acid (IdoA) is the major uronic acid component of the glycosaminoglycans (GAGs) dermatan sulfate, and heparin. It is also present in heparan sulfate although here in a minor amount relative to its carbon-5 epimer glucuronic acid. IdoA is a hexapyranose sugar. Most hexapyranoses are stable in one of two chair conformations 1C4 or 4C1. L-iduronate is different and adopts more than one solution conformation, with an equilibrium existing between three low-energy conformers. These are the 1C4 and 4C1 chair forms and an additional 2S0 skew-boat conformation. IdoA may be modified by the addition of an O-sulfate group at carbon position 2 to form 2-O-sulfo-L-iduronic acid (IdoA2S). In 2000, LK Hallak described the importance of this sugar in respiratory syncytial virus infection. Dermatan sulfate and heparan sulfate were the only GAGs containing IdoA, and they were the only ones that inhibited RSV infection in cell culture. When internally positioned within an oligosaccharide, the 1C4 and 2S0 conformations (shown below for IdoA2S) predominate. Proton NMR spectroscopy can be used to track changes in the balance of this equilibrium.
• Synonyms:L-idopyranuronic acid; L-Iduronic acid, D-ido-Hexuronic acid; IdoA
• Molecular Formula:C6H10O7
• Molecular Weight:194.14
• Purity (TLC):≥98%
• Appearance:White to off-white crystalline powder
• Melting Point:As Reported
• Method for Determining Identity:Proton NMR (D2O) Spectroscopic Analysis
• Storage and Stability:Store at 4ºC. Stable for 6 months after receipt.
• Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
• Toxicity and Hazards:All products should be handled by qualified personnel only, trained in laboratory procedures.