85-4039-59　Regorafenib 50mg　CAS No:755037-03-7　288607

特徴

• Inhibits PDGFR tyrosine kinase with IC50=83nM. It is useful for the treatment of inflammation and as an anti-proliferative agent.
• Synonyms:4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide; 4-[4-[N’-(4-Chloro-3-trifluoromethylphenyl)ureido]-3-fluorophenoxy]pyridine-2-carboxylic Acid Methylamide; BAY 73-4506; Fluoro-Sorafenib; Stivarga
• Molecular Formula:C₂₁H₁₅ClF₄N₄O₃
• Molecular Weight:482.82
• Appearance:Supplied as a white to off-white powder.
• Purity:≥99% (HPLC, TLC)
• Melting Point:185-186ºC
• Solubility:DMSO
• Elemental Analysis:Calculated:%C: 52.24%H: 3.13%Cl: 7.34%F: 15.74%N: 11.60
• Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.