85-3969-41　Posaconazole 250mg　CAS No:171228-49-2　286988

特徴

• Anti-fungal agent; sterol α-demethylase inhibitor. Posaconazole is a highly potent broadspectrum antifungal drug. It blocks the synthesis of ergosterol by inhibiting of the enzyme lanosterol 14α-demethylase resulting in accumulation of methylated sterol precursors. In contrast to other antifungal azoles, posaconazole has been reported not to induce the efflux pump mechanism. Posaconazole was able to produce a parasitological cure in a mouse model of the chronic stage of Chagas disease.
• Synonyms:2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol; Noxafil; Sch 56592
• Molecular Formula:C₃₇H₄₂F₂N₈O₄
• Molecular Weight:700.78
• Appearance:White to off-white powder
• Purity:≥98%
• Melting Point:166-168°C
• Water:≤2%
• Solubility:Chloroform (Slightly), Methanol (Slightly)
• Storage:-20°C