85-3932-95　Oxybutynin Chloride 10g　CAS No:1508-65-2　286164

特徴

• An antagonist of muscarinic acetylcholine receptors, anti-spasmodic. An inhibitor of proliferation and supresses gene expression in bladder smooth muscle cells.
• Oxybutynin is an antagonist of muscarinic acetylcholine receptors (Kis = 5, 14.5, 3.7, 5.3, and 40nM for human recombinant M1-5, respectively).1 It inhibits intracellular calcium mobilization induced by carbamoylcholine in bladder smooth muscle and submandibular gland cells isolated from cynomolgus monkeys (Kis = 2 and 1nM, respectively).2 Oxybutynin inhibits volume-induced bladder contraction (VIBC) and oxotremorine-induced salivation (OIS) in rats (ID50s = 0.062 and 0.089mg/kg, respectively).1 It also increases pupil diameter (PD) and locomotor activity (LMA; ED50s = 0.29 and 0.52mg/kg, respectively) and decreases small intestinal transit (SIT; ID50 = 0.22mg/kg) in rats. Formulations containing oxybutynin have been used in the treatment of overactive bladder.
• Synonyms:α-Phenylcyclohexaneglycolic acid 4-(diethylamino)-2-butynyl ester hydrochloride; 4-(diethylamino)-2-butyn-1-yl ester α-cyclohexyl-α-hydroxy-benzeneacetic acid, monohydrochloride; MJ4309-1
• Molecular Formula:C₂₂H₃₂ClNO₃
• Molecular Weight:393.95
• Appearance:White to off-white crystalline powder
• Purity:≥98%
• Solubility:Soluble in water (50mg/ml). Methanol (Slightly), Chloroform (Slightly)
• Storage and Stability:Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.