85-3885-41　［取扱停止］Navitoclax (ABT 263) 50mg　CAS No:923564-51-6　285063

特徴

• A novel inhibitor of antiapoptotic BCL-2 proteins; a new promising anticancer drug candidate. Potent Bcl-2 family inhibitor.
• Synonyms:4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide; Navitoclax
• Molecular Formula:C₄₇H₅₅ClF₃N₅O₆S₃
• Molecular Weight:974.61
• Appearance:Pale Yellow to Pale Brown Solid
• Purity:≥98%
• Melting Point:>124°C (dec.)
• Solubility:Chloroform, DMSO, Methanol
• Method for Determining Identity:Proton NMR (DMSO-d6), 19F NMR (DMSO-d6) Spectroscopic and Mass Spectrometric Analysis
• TLC Conditions:SiO2; Dichloromethane: Methanol: Ammonium Hydroxide = 9:1:0.1; Visualized with UV and AMCS; Single Spot, Rf=0.55..
• Atmosphere:Inert gas
• Specific Rotation (c=0.25, Chloroform):-48.1º
• Ethyl Acetate Content:~2.5%
• Storage and Stability:Powder may be stored at -20°C. Stable for 6 months after receipt at -20°C. Hygroscopic. Note: Inert atmosphere is preferred for long term storage
• Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
• Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.