85-3590-49　GW 501516 10mg　CAS No:317318-70-0　278374

特徴

• An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα and PPARγ. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells.
• Synonyms:2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic Acid; Methyl-methyl-trifluoromethylphenyl-thiazolyl-methylsulfanyl-phenoxy-acetic Acid; GW 1516; Endurobol
• Molecular Formula:C₂₁H₁₈F₃NO₃S₂
• Molecular Weight:453.5
• Appearance:White to yellow powder
• Purity:≥98%
• Melting Point:134-144°C
• Solubility:DMSO (Slightly), Methanol (Slightly)
• Water:≤0.5%
• Storage and Stability:May be stored at 4°C for short-term. For long-term storage, aliquot and store at -20°C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.